Which federal regulation addresses the response to hazardous substance releases?

The regulation that addresses the response to hazardous substance releases is found in 40 CFR 300. This specific part of the Code of Federal Regulations outlines the National Oil and Hazardous Substances Pollution Contingency Plan (NCP), which establishes the framework for the federal government's response to hazardous substance releases. This includes guidelines for the preparation and implementation of response actions to mitigate the effects of such releases, ensuring that both the response to spills and the restoration of affected environments are conducted effectively.

The other options pertain to different regulations; for instance, 33 CFR 155 focuses on oil spill response efforts and prevention measures for vessels, while 40 CFR 1500 relates to the National Environmental Policy Act (NEPA) regulations. Thus, these do not specifically address the comprehensive response to hazardous substance releases in the same capacity as 40 CFR 300.